Which syndrome can result in hearing loss if cholesteatoma is present?

Usher syndrome is associated with hearing loss due to its impact on the inner ear structures, which are critical for sound perception. In the context of cholesteatoma, this formed cyst-like growth in the middle ear can lead to destruction of surrounding structures, potentially affecting hearing and balance.

Cholesteatoma can cause conductive hearing loss by damaging the ossicles, which are key in sound transmission. Additionally, as the condition progresses, it may lead to complications such as infections or further damage that could impact the auditory pathways, leading to sensorineural hearing loss. Given that Usher syndrome inherently includes both hearing loss and visual impairment, individuals with this syndrome are at greater risk for compounded hearing deficits due to conditions like cholesteatoma.

The other syndromes listed may have various associated medical issues, but their connections to hearing loss specifically in the presence of a cholesteatoma are not as direct or significant as they are in Usher syndrome. For example, Down syndrome may include hearing difficulties, but these are typically due to anatomical variations rather than the complications that arise from a cholesteatoma.