Which physical sign is associated with Cushing's Syndrome?

Cushing's Syndrome is characterized by an excess of cortisol in the body, often leading to a variety of distinct physical signs, one of the most recognizable being moon facies. This refers to a rounded, smooth facial appearance that often gives the face a full and swollen look. The accumulation of fat due to increased cortisol levels tends to create this distinctive appearance, making it a key indicator of Cushing's Syndrome during physical examination.

In contrast, the other signs listed do not typically associate with Cushing's Syndrome. A goiter is related to thyroid dysfunction, such as hypo or hyperthyroidism, which does not connect to cortisol levels. Puffy eyelids are not a hallmark of Cushing's Syndrome and can result from various conditions unrelated to hormonal imbalances. Facial flushing is more often associated with conditions like pheochromocytoma or rosacea, rather than the hormonal disturbances seen in Cushing's. Thus, moon face serves as a critical physical sign for clinicians to recognize when suspecting this endocrine disorder.