Which medication is commonly used for migraine prophylaxis?

Amitriptyline is commonly used for migraine prophylaxis due to its effects on neurotransmitters that are involved in pain perception. It is a tricyclic antidepressant that has been shown to reduce the frequency and severity of migraine attacks by modulating serotonin and norepinephrine levels in the brain, which can help in stabilizing mood and managing pain pathways. This medication is often chosen for patients who experience frequent or debilitating migraines, as it can significantly decrease the number of headache days per month when used consistently.

While ibuprofen is an effective medication for acute migraine relief due to its anti-inflammatory properties, it is not typically used for prophylaxis. Antihistamines are primarily used for allergic reactions and may not effectively prevent migraines. Oral corticosteroids are sometimes utilized in certain acute situations but are not a standard choice for migraine prevention due to potential long-term side effects associated with their use. Therefore, amitriptyline is the preferred option for prophylactic treatment in managing migraines.