Which antibiotic is commonly used to treat sinusitis in patients without an allergy?

Amoxicillin is commonly used as the first-line treatment for acute bacterial sinusitis in patients who do not have a penicillin allergy. This choice is favored due to its effectiveness against the most prevalent pathogens associated with sinus infections, including Streptococcus pneumoniae and Haemophilus influenzae. Amoxicillin's pharmacokinetics allow for good tissue penetration and its dosing regimen is typically based on a standard duration of 5 to 7 days, making it convenient and effective for treating an acute condition like sinusitis.

Other antibiotics listed can also be used in the treatment of sinusitis but are usually not the first choice. Ciprofloxacin may be utilized in cases of resistant bacteria or specific patient circumstances, but it is generally reserved for more complex infections. Doxycycline is effective against a variety of pathogens and is an alternative for patients with penicillin allergies, but it is not typically the first-line treatment choice for uncomplicated sinusitis. Azithromycin may provide coverage for atypical organisms but is often not as effective as amoxicillin for the common bacterial causes of sinusitis. Therefore, amoxicillin is preferred for its targeted action and established efficacy.