What is the first-line treatment for Polymyalgia Rheumatica?

Polymyalgia Rheumatica (PMR) is characterized by muscle pain and stiffness, particularly in the shoulders and hips, and is often associated with inflammation. The first-line treatment for PMR is corticosteroids, with prednisone being the most commonly prescribed.

Prednisone is effective in rapidly alleviating symptoms of PMR, including pain and stiffness. The anti-inflammatory properties of corticosteroids address the underlying inflammation that contributes to the symptoms. Typically, treatment initiates with a low dose of prednisone, and symptoms usually improve significantly within days. This rapid response is a hallmark of the disorder and further supports the use of prednisone as the initial therapy.

While NSAIDs can provide some pain relief, they are generally not as effective in treating the inflammation seen in PMR. Physical therapy can be beneficial for maintaining mobility and function, but it is not a standalone treatment for the inflammatory aspects of the disease. Topical analgesics may help alleviate localized pain but do not address the systemic inflammation associated with PMR, making them less appropriate as a first-line treatment.

Therefore, prednisone therapy is recognized as the most effective and appropriate first-line treatment for Polymyalgia Rheumatica.