What is a major concern with untreated high-grade squamous lesions?

Untreated high-grade squamous lesions, particularly in the context of cervical health, pose a significant risk of developing cervical cancer. High-grade lesions indicate more severe cellular changes, which are considered precursors to cancer. If these lesions are not monitored or treated, they can progress to invasive cervical cancer over time. This progression is why early detection and management of high-grade squamous lesions through procedures such as colposcopy and biopsy are crucial.

The importance of addressing these lesions lies in the potential for them to evolve into malignancy if left untreated, making vigilant screening and intervention essential components of women's healthcare. In contrast, the other options are not directly related to the implications of high-grade squamous lesions. A skin rash, increased fertility, and chronic headaches do not correlate with the cellular changes that characterize these lesions or their associated risks.