What do you check for with a Direct Coombs test?

The Direct Coombs test is specifically designed to detect the presence of antibodies bound to the surface of red blood cells. This test is primarily used in the diagnosis of hemolytic anemias, which can occur due to autoimmune conditions, certain medications, or transfusion reactions. When antibodies attack red blood cells, the Direct Coombs test reveals that these antibodies are present in the blood sample being tested.

The other options relate to different clinical evaluations. Checking for the presence of bilirubin, for instance, is often done to assess liver function or hemolysis, but it does not specifically indicate whether antibodies are bound to red blood cells. Similarly, a red blood cell count measures the number of red blood cells in circulation but does not provide direct information about the immune response or antibody interactions. Blood glucose levels relate to metabolic health and diabetes management, which is completely separate from what the Direct Coombs test assesses. Thus, the focus of the Direct Coombs test is clearly on identifying antibodies, making the option regarding the presence of antibodies the correct choice.